Significant correlation between median v(e) and IFP was not found for any of the contrast agents (p > 0.05 for Gd-DTPA, P846, and gadomelitol). Significant inverse correlations were found between median K(trans) and IFP for Gd-DTPA (p = 0.0076 R(2) = 0.46 n = 14) and P846 (p = 0.0042 R(2) = 0.45 n = 16), whereas there was no correlation between median K(trans) and IFP for gadomelitol (p > 0.05 n = 16). Parametric images of K(trans) (the volume transfer constant of the contrast agent) and v(e) (the fractional distribution volume of the contrast agent) were produced by pharmacokinetic analysis of the DCE-MRI series. A total of 46 tumors were subjected to DCE-MRI and subsequent measurement of IFP. Three contrast agents were compared: Gd-DTPA (0.55 kDa), P846 (3.5 kDa), and gadomelitol (6.5 kDa). The purpose of this preclinical study was to investigate whether any association between DCE-MRI-derived parametric images and tumor IFP can be strengthened by using MR contrast agents with higher molecular weights than that of Gd-DTPA.Ī-07 human melanoma xenografts were used as preclinical models of human cancer. There is some evidence that gadolinium diethylene-triamine penta-acetic acid (Gd-DTPA)-based dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) may be a useful non-invasive method for providing information on the IFP of tumors.

Cancer patients showing highly elevated interstitial fluid pressure (IFP) in the primary tumor may benefit from particularly aggressive treatment.

Interstital fluid image